Imidacloprid and Moxidectin Drops Spot-On Solution (Cat Dog)
                                                                        Pet External Use Drug
Name:  Imidacloprid and Moxidectin Spot-on Solutions(for Cats)
Compostion: Imidacloprid , Moxidectin 
Character: This product is yellow to brown liquid.
Pharmacological effects antiparasite drug
Pharmacodynamics: Imidacloprid is a new generation of chlorinated nicotine insecticide, which affects the postsynaptic nicotinic acetylcholine in the central nervous system of insects.
Alkali receptors have high affinity and inhibit acetylcholine activity, leading to paralysis and death of the parasite. It is effective against adult fleas and juvenile fleas in all stages, and also has a killing effect on juvenile fleas in the environment. The mechanism of action of moxidectin is similar to that of avermectin and ivermectin. It has a good repellent effect on internal and external parasites, especially nematodes and arthropods. Its mechanism of anthelmintic action is to promote the neurotransmitter γ-amino acid. The release of butyrate (GABA) increases its binding force to postsynaptic receptors and opens chloride channels. Moxidectin also has selectivity and high affinity for glutamate-mediated chloride channels, thereby interfering with neuromuscular signal transmission, causing relaxation and paralysis of the worm, leading to death of the worm. Inhibitory interneurons and excitatory motor neurons in nematodes are its sites of action, while in arthropods the site of action is the neuromuscular junction. The two are used together to have a synergistic effect.
Pharmacokinetics: After the first dose, imidacloprid is rapidly distributed to the cat's body surface on the same day and remains on the cat's body surface between doses. 1 to 2 days after administration, the plasma concentration of moxidectin reaches its highest level in cats, and is distributed throughout the body and slowly metabolized and excreted within a month.
Indications For the prevention and treatment of internal and external parasitic infections in dogs. Prevention and treatment of flea infestations (Ctenophora felis), treatment of tick infestations (Trichopterus canis), treatment of ear mite infestations (T. auris), canine sarcoptic mange (Scabies) and demodicosis (Demodex canis) , treatment of Angiostrongylus and gastrointestinal nematode infections (adult worms, immature adults and L4 stage larvae of Toxocara canis, Ancylostoma canis and Ancylostoma canis; adults of Toxocara leonata and Trichocystis lepiensis), prevention of heart disease Filariasis (L3 and L4 stage larvae of Dirofilaria immitis), treatment of circulating microfilariae (Dirofilaria immitis). It can also assist in the treatment of allergic dermatitis caused by fleas.
Usage & Dosage Based on this product. External use: One dose, 0.1ml per 1kg body weight for dogs. During prevention or treatment, administer once a month. To prevent dogs from licking, this product can be dropped on the skin from between the shoulder blades to the buttocks on the dog's back, and can be added in 3 to 4 places. Please refer to the instruction manual for details of dosing regimen.

Cat B.W.(kg)	Applicable product type	Volume(ml)	Imidacloprid (mg/kg B.W.)	Moxidectin(mg/kg B.W.)
≤4kg	For little dogs	0.4 ml	Not less than 10	Not less than 2.5
>4~10kg	For middle dogs	1.0 ml	10~25	2.5~6.25
>10~25kg	For large dogs	2.5 ml	10~25	2.5~6.25
>25~40kg	For extra large dogs	4.0 ml	10~16	2.5~4.0
>40 kg	Use a combination of products with appropriate specifications